Global Initiative for Obstructive Lung Disease (GOLD) Criteria for COPD

Treatment recommendations based on COPD stage.

Audience: PRACTITIONER

Published by EVAL Foundation

Revision 3 · Published November 5, 2024

Summary

 The Global Initiative for Chronic Obstructive Pulmonary Lung Disease (GOLD) Criteria were first published in 2001 to assist clinicians in assessing and characterizing the severity of Chronic Obstructive Pulmonary Disease (COPD). Once COPD is diagnosed by spirometry (FEV1/FVC <0.7), the GOLD Criteria can be used to predict the risk of future COPD exacerbations and classify patients into therapeutic treatment groups (A,B & E). The Global ABE Assessment Process includes assessment of airflow obstruction by stage (GOLD 1-4) based on FEV1. The final step involves two dyspnea scales called the COPD Assessment Test (CAT) or the Modified Medical Research Council (mMRC) Dyspnea Scale in conjunction with the patient's exacerbation history to guide therapeutic interventions for management of stable, baseline COPD. In addition, the Global ABE Assessment includes the use of blood eosinophils to assist in identifying high risk patients that may benefit from additional Inhaled Corticosteroid (ICS) therapy.

 

Of note, the Global ABE Assessment Process:

 

FORMULA

 

GRADEFEV1 (% predicted)
GOLD 1≥80
GOLD 250-79
GOLD 330-49
GOLD 4<30

 

GROUPCRITERIA
A
  • 0 OR 1 moderate (not leading to hospitalization) exacerbations

                                                  AND

  • mMRC 0-1 OR CAT <10
B
  • 0 OR 1 moderate (not leading to hospitalization) exacerbations

                                                  AND

  • mMRC ≥2 OR CAT ≥10
E
  • ≥2 moderate OR ≥1 leading to hospitalization exacerbations

                                                  AND

  • Eos ≤ 300 OR unknown
E (Eos  ≥300) 
  • ≥2 moderate OR ≥1 leading to hospitalization exacerbations

                                                  AND

  • Eos ≥ 300 

 

RECOMMENDATIONS

 

GOLD 

GROUP

RISKPHARMACOLOGIC TREATMENTNONPHARMACOLOGIC TREATMENT
ALow risk, low exacerbation frequency, no hospitalizations, low symptom burden.Bronchodilator
  • Essential: Smoking Cessation
  • Recommended: Physical Activity
  • Depending on Local Guidelines:
    • Influenza vaccination
    • COVID-19 vaccinations
    • Pneumococcal vaccination
    • Pertussis vaccination
    • Shingles vaccination
    • RSV vaccination

 

BLow risk, low exacerbation frequency, no hospitalizations, increase symptom burden.Long-acting bronchodilator (LABA) AND long-acting methacholine antagonist (LAMA)
  • Essential: Smoking Cessation
  • Recommended: 
    • Physical Activity
    • Pulmonary Rehabilitation
  • Depending on Local Guidelines:
    • Influenza vaccination
    • COVID-19 vaccinations
    • Pneumococcal vaccination
    • Pertussis vaccination
    • Shingles vaccination
    • RSV vaccination
CHigh risk, increased exacerbation frequency leading to hospitalization, variable symptom burden.Long-acting bronchodilator (LABA) AND long-acting methacholine antagonist (LAMA)
  • Essential: Smoking Cessation
  • Recommended: 
    • Physical Activity
    • Pulmonary Rehabilitation
  • Depending on Local Guidelines:
    • Influenza vaccination
    • COVID-19 vaccinations
    • Pneumococcal vaccination
    • Pertussis vaccination
    • Shingles vaccination
    • RSV vaccination
EHigh risk, increased exacerbation frequency leading to hospitalization, variable symptom burden.
  1. Long-acting bronchodilator (LABA) AND long-acting methacholine antagonist (LAMA)
  • Essential: Smoking Cessation
  • Recommended: 
    • Physical Activity
    • Pulmonary Rehabilitation
  • Depending on Local Guidelines:
    • Influenza vaccination
    • COVID-19 vaccinations
    • Pneumococcal vaccination
    • Pertussis vaccination
    • Shingles vaccination
    • RSV vaccination
E (Eos  ≥300)High risk, increased exacerbation frequency leading to hospitalization, variable symptom burden.
  1. Long-acting bronchodilator (LABA) AND long-acting methacholine antagonist (LAMA)
  2. AND Inhaled corticosteroid (ICS)
  • Essential: Smoking Cessation
  • Recommended: 
    • Physical Activity
    • Pulmonary Rehabilitation
  • Depending on Local Guidelines:
    • Influenza vaccination
    • COVID-19 vaccinations
    • Pneumococcal vaccination
    • Pertussis vaccination
    • Shingles vaccination
    • RSV vaccination

 

GLOBAL RECOMMENDATIONS

 

Goals for Treatment of Stable COPD:

  1. Reduce Symptoms
    1. Relieve Symptoms
    2. Improve Exercise Tolerance
    3. Improve Health Status
  2. Reduce Risk
    1. Prevent Disease Progression
    2. Prevent & Treat Exacerbations
    3. Reduce Mortality

 

Review:

  1. Risk factor management
    1. ∝1-antitrypsin
    2. blood eosinophil count
    3. exposures/irritants
  2. Inhaler technique & adherence
  3. Self management skills
    1. breathlessness
    2. written action plan
  4. Need for oxygen, NIV, lung volume reduction, palliative approaches
  5. Management of comorbidities
  6. Spirometry (at least annually)

 

Refer to the 2024 guidelines for more information.

 

Instructions

 

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Revisions

Current: Revision 3

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