Treatment recommendations based on COPD stage.
Audience: PRACTITIONER
Published by EVAL Foundation
Revision 3 · Published November 5, 2024
The Global Initiative for Chronic Obstructive Pulmonary Lung Disease (GOLD) Criteria were first published in 2001 to assist clinicians in assessing and characterizing the severity of Chronic Obstructive Pulmonary Disease (COPD). Once COPD is diagnosed by spirometry (FEV1/FVC <0.7), the GOLD Criteria can be used to predict the risk of future COPD exacerbations and classify patients into therapeutic treatment groups (A,B & E). The Global ABE Assessment Process includes assessment of airflow obstruction by stage (GOLD 1-4) based on FEV1. The final step involves two dyspnea scales called the COPD Assessment Test (CAT) or the Modified Medical Research Council (mMRC) Dyspnea Scale in conjunction with the patient's exacerbation history to guide therapeutic interventions for management of stable, baseline COPD. In addition, the Global ABE Assessment includes the use of blood eosinophils to assist in identifying high risk patients that may benefit from additional Inhaled Corticosteroid (ICS) therapy.
Of note, the Global ABE Assessment Process:
FORMULA
| GRADE | FEV1 (% predicted) |
| GOLD 1 | ≥80 |
| GOLD 2 | 50-79 |
| GOLD 3 | 30-49 |
| GOLD 4 | <30 |
| GROUP | CRITERIA |
| A |
AND
|
| B |
AND
|
| E |
AND
|
| E (Eos ≥300) |
AND
|
RECOMMENDATIONS
GOLD GROUP | RISK | PHARMACOLOGIC TREATMENT | NONPHARMACOLOGIC TREATMENT |
| A | Low risk, low exacerbation frequency, no hospitalizations, low symptom burden. | Bronchodilator |
|
| B | Low risk, low exacerbation frequency, no hospitalizations, increase symptom burden. | Long-acting bronchodilator (LABA) AND long-acting methacholine antagonist (LAMA) |
|
| C | High risk, increased exacerbation frequency leading to hospitalization, variable symptom burden. | Long-acting bronchodilator (LABA) AND long-acting methacholine antagonist (LAMA) |
|
| E | High risk, increased exacerbation frequency leading to hospitalization, variable symptom burden. |
|
|
| E (Eos ≥300) | High risk, increased exacerbation frequency leading to hospitalization, variable symptom burden. |
|
|
GLOBAL RECOMMENDATIONS
Goals for Treatment of Stable COPD:
Review:
Refer to the 2024 guidelines for more information.
Current: Revision 3
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