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Steroid Dosage Conversion

Converts steroid dosages using dosing equivalencies

创建者Dr. Bryan D. Hayes, PharmD, FAACT, FASHP
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Introduction

Patients using steroid medications may need to have doses converted to another steroid for various reasons, such as formulation (IV, oral, liquid or pill) or drug availability. This may be required whether a patient is on a short "burst" dose or taking medication long-term.

Different glucocorticoids or steroid medication exhibit a range of duration of effect and potency. Both factors ought to be considered when converting steroid medications. 

  • IV and oral administration dosing relationships only apply for this use case. 

  • Intra-muscular and intra-articular routes are not included due to significant differences in potency compared to IV and oral routes.

  • Fludrocortisone is not included as it is used for its mineralocorticoid properties and not its glucocorticoid effects

 

Rules for Corticosteroid Conversions:

Medication

Route

Equivalent(Eq) Dose (mg)

Duration of Action

Betamethasone

IV

0.75

Long (36-72 Hours)

Cortisone

PO

25

Short (8-12 Hours)

Dexamethasone (Decadron)

IV or PO

0.75

Long (36-72 Hours)

Hydrocortisone

IV or PO

20

Short (8-12 Hours)

MethylPrednisoLONE (Solu-Medrol)

IV or PO

4

Medium (12-36 Hours)

PrednisoLONE

PO

5

Medium (12-36 Hours)

PredniSONE

PO

5

Medium (12-36 Hours)

Triamcinolone

IV

4

Medium (12-36 Hours)

 

Formula: 

Convert To Dosage (mg) =  Convert From Dose (mg) / (Convert From Eq Dose (mg) / Convert To Eq Dose (mg)) 

 

所有问题及可能的结果

Questions标题不可见
Select medication to convert from.

Select one option:

  • Betamethasone (IV)
  • Cortisone (PO)
  • Dexamethasone (Decadron) IV or PO
  • Hydrocortisone (IV or PO)
  • MethylPrednisoLONE (Solu-Medrol) IV or PO
  • PrednisoLONE (PO)
  • PredniSONE (PO)
  • Triamcinolone (IV)
Enter drug dosage in mg.

A number between 0 and 1000, in mg.

Select medication to convert to.

Select one option:

  • Betamethasone (IV)
  • Cortisone (PO)
  • Dexamethasone (Decadron) IV or PO
  • Hydrocortisone (IV or PO)
  • MethylPrednisoLONE (Solu-Medrol) IV or PO
  • PrednisoLONE (PO)
  • PredniSONE (PO)
  • Triamcinolone (IV)
可能的结果
Approximate MethylPrednisoLONE (Solu-Medrol) (IV or PO) Equivalence to Triamcinolone (IV)
Approximate MethylPrednisoLONE (Solu-Medrol)(IV or PO) Equivalence to Betamethasone (IV)

You are converting to a drug with a shorter half-life, consider increasing dosing frequency.

 

Duration of Action:

  • MethylPrednisoLONE: Medium (12-36 Hours)
  • Betamethasone: Long (36-72 Hours)
Approximate PredniSONE (PO) Equivalence to Triamcinolone (IV)
Approximate Triamcinolone (IV) Equivalence to Dexamethasone (Decadron) (IV or PO)

You are converting to a drug with a shorter half-life, consider increasing dosing frequency.

 

Duration of Action:

  • Triamcinolone: Medium (12-36 Hours)
  • Dexamethasone: Long (36-72 Hours)
Approximate Cortisone (PO) Equivalence to PredniSONE (PO)

You are converting to a drug with a shorter half-life, consider increasing dosing frequency.

 

Duration of Action:

  • Cortisone: Short (8-12 Hours)
  • PredniSONE: Medium (12-36 Hours)
Approximate Betamethasone (IV) Equivalence to Hydrocortisone (IV or PO)

You are converting to a drug with a longer half-life, consider reducing dosing frequency.

 

Duration of Action:

  • Betamethasone: Long (36-72 Hours)
  • Hydrocortisone: Short (8-12 Hours)
Approximate Triamcinolone (IV) Equivalence to Betamethasone (IV)

You are converting to a drug with a shorter half-life, consider increasing dosing frequency.

 

Duration of Action:

  • Triamcinolone: Medium (12-36 Hours)
  • Betamethasone: Long (36-72 Hours)
Approximate MethylPrednisoLONE (Solu-Medrol)(IV or PO) Equivalence to Hydrocortisone (IV or PO)

You are converting to a drug with a longer half-life, consider reducing dosing frequency.

 

Duration of Action:

  • MethylPrednisoLONE: Medium (12-36 Hours)
  • Hydrocortisone: Short (8-12 Hours)
Approximate Betamethasone (IV) Equivalence to Dexamethasone (Decadron) (IV or PO)
Approximate PredniSONE (PO) Equivalence to Hydrocortisone (IV or PO)

You are converting to a drug with a longer half-life, consider reducing dosing frequency.

 

Duration of Action:

  • PredniSONE: Medium (12-36 Hours)
  • Hydrocortisone: Short (8-12 Hours)
Approximate Betamethasone (IV) Equivalence to Triamcinolone (IV)

You are converting to a drug with a longer half-life, consider reducing dosing frequency.

 

Duration of Action:

Betamethasone: Long (36-72 Hours)
Triamcinolone: Medium (12-36 Hours)

Approximate Dexamethasone (Decadron) (IV or PO) Equivalence to Betamethasone (IV)
Approximate Dexamethasone (Decadron) (IV or PO) Equivalence to PredniSONE (PO)

You are converting to a drug with a longer half-life, consider reducing dosing frequency.

 

Duration of Action:

Dexamethasone: Long (36-72 Hours)
PredniSONE: Medium (12-36 Hours)

Approximate Dexamethasone (Decadron) (IV or PO) Equivalence to Triamcinolone (IV)

You are converting to a drug with a longer half-life, consider reducing dosing frequency.

 

Duration of Action:

Dexamethasone: Long (36-72 Hours)
Triamcinolone: Medium (12-36 Hours)

Approximate Hydrocortisone (IV or PO) Equivalence to Triamcinolone (IV)

You are converting to a drug with a shorter half-life, consider increasing dosing frequency.

 

Duration of Action:

  • Hydrocortisone: Short (8-12 Hours)
  • Triamcinolone: Medium (12-36 Hours)
Approximate Cortisone (PO) Equivalence to PrednisoLONE (PO)

You are converting to a drug with a shorter half-life, consider increasing dosing frequency.

 

Duration of Action:

  • Cortisone: Short (8-12 Hours)
  • MethylPrednisoLONE: Medium (12-36 Hours)
Approximate PrednisoLONE (IV or PO) Equivalence to Cortisone (PO)

You are converting to a drug with a longer half-life, consider reducing dosing frequency.

 

Duration of Action:

  • PrednisoLONE: Medium (12-36 Hours)
  • Cortisone: Short (8-12 Hours)
Approximate MethylPrednisoLONE (Solu-Medrol) (IV or PO) Equivalence to Cortisone (PO)

You are converting to a drug with a longer half-life, consider reducing dosing frequency.

 

Duration of Action:

  • MethylPrednisoLONE: Medium (12-36 Hours)
  • Cortisone: Short (8-12 Hours)
Approximate PrednisoLONE (PO) Equivalence to Hydrocortisone (IV or PO)

You are converting to a drug with a longer half-life, consider reducing dosing frequency.

 

Duration of Action:

  • PrednisoLONE: Medium (12-36 Hours)
  • Hydrocortisone: Short (8-12 Hours)
Approximate MethylPrednisoLONE (Solu-Medrol) (IV or PO) Equivalence to PredniSONE (PO)
Approximate Triamcinolone (IV) Equivalence to MethylPrednisoLONE (Solu-Medrol) (IV or PO)
Approximate PredniSONE (PO) Equivalence to PrednisoLONE (PO)
Approximate Betamethasone (IV) Equivalence to PrednisoLONE (PO)

You are converting to a drug with a longer half-life, consider reducing dosing frequency.

 

Duration of Action:

Betamethasone: Long (36-72 Hours)
PrednisoLONE: Medium (12-36 Hours)

Approximate Dexamethasone (Decadron) (IV or PO) Equivalence to Hydrocortisone (IV or PO)

You are converting to a drug with a longer half-life, consider reducing dosing frequency.

 

Duration of Action:

  • Dexamethasone: Long (36-72 Hours)
  • Hydrocortisone: Short (8-12 Hours)
Approximate PredniSONE (PO) Equivalence to Cortisone (PO)

You are converting to a drug with a longer half-life, consider reducing dosing frequency.

 

Duration of Action:

  • PredniSONE: Medium (12-36 Hours)
  • Cortisone: Short (8-12 Hours)
Approximate Hydrocortisone (IV or PO) Equivalence to Dexamethasone (Decadron) (IV or PO)

You are converting to a drug with a shorter half-life, consider increasing dosing frequency.

 

Duration of Action:

  • Hydrocortisone: Short (8-12 Hours)
  • Dexamethasone: Long (36-72 Hours)
Approximate PrednisoLONE (PO) Equivalence to MethylPrednisoLONE (Solu-Medrol) (IV or PO)
Approximate Cortisone (PO) Equivalence to Hydrocortisone (IV or PO)
Approximate Cortisone (PO) Equivalence to Betamethasone (IV)

You are converting to a drug with a shorter half-life, consider increasing dosing frequency.

 

Duration of Action:

  • Cortisone: Short (8-12 Hours)
  • Betamethasone: Long (36-72 Hours)
Approximate Cortisone (PO) Equivalence to Dexamethasone (Decadron) (IV or PO)

You are converting to a drug with a shorter half-life, consider increasing dosing frequency.

 

Duration of Action:

  • Cortisone: Short (8-12 Hours)
  • Dexamethasone: Long (36-72 Hours)
Approximate PrednisoLONE (IV or PO) Equivalence to Triamcinolone (IV)
Approximate Hydrocortisone (IV or PO) Equivalence to Cortisone (PO)
Approximate PredniSONE (PO) Equivalence to MethylPrednisoLONE (Solu-Medrol) (IV or PO)
Approximate Triamcinolone (IV) Equivalence to Cortisone (PO)

You are converting to a drug with a longer half-life, consider reducing dosing frequency.

 

Duration of Action:

  • Triamcinalone: Medium (12-36 Hours)
  • Cortisone: Short (8-12 Hours)
Approximate MethylPrednisoLONE (Solu-Medrol) (IV or PO) Equivalence to Dexamethasone (Decadron) (IV or PO)

You are converting to a drug with a shorter half-life, consider increasing dosing frequency.

 

Duration of Action:

  • MethylPrednisoLONE: Medium (12-36 Hours)
  • Dexamethasone: Long (36-72 Hours)
Approximate Triamcinolone (IV) Equivalence to PrednisoLONE (PO)
Approximate Betamethasone (IV) Equivalence to Cortisone (PO)

You are converting to a drug with a longer half-life, consider reducing dosing frequency.

 

Duration of Action:

  • Betamethasone: Long (36-72 Hours)
  • Cortisone: Short (8-12 Hours)
Approximate PrednisoLONE (IV or PO) Equivalence to Dexamethasone (Decadron) (IV or PO)

You are converting to a drug with a shorter half-life, consider increasing dosing frequency.

 

Duration of Action:

  • PrednisoLONE: Medium (12-36 Hours)
  • Dexamethasone: Long (36-72 Hours)
Approximate Cortisone (PO) Equivalence to MethylPrednisoLONE (Solu-Medrol) (IV or PO)

You are converting to a drug with a shorter half-life, consider increasing dosing frequency.

 

Duration of Action:

  • Cortisone: Short (8-12 Hours)
  • MethylPrednisoLONE: Medium (12-36 Hours)
Approximate Dexamethasone (Decadron) (IV or PO) Equivalence to PrednisoLONE (PO)

You are converting to a drug with a longer half-life, consider reducing dosing frequency.

 

Duration of Action:

Dexamethasone: Long (36-72 Hours)
PrednisoLONE: Medium (12-36 Hours)

Approximate Triamcinolone (IV) Equivalence to Hydrocortisone (IV or PO)

You are converting to a drug with a longer half-life, consider reducing dosing frequency.

 

Duration of Action:

  • Triamcinalone: Medium (12-36 Hours)
  • Hydrocortisone: Short (8-12 Hours)
Approximate Triamcinolone (IV) Equivalence to PredniSONE (PO)
Approximate Hydrocortisone (IV or PO) Equivalence to PredniSONE (PO)

You are converting to a drug with a shorter half-life, consider increasing dosing frequency.

 

Duration of Action:

  • Hydrocortisone: Short (8-12 Hours)
  • PredniSONE: Medium (12-36 Hours)
Approximate PredniSONE (PO) Equivalence to Betamethasone (IV)

You are converting to a drug with a shorter half-life, consider increasing dosing frequency.

 

Duration of Action:

  • PredniSONE: Medium (12-36 Hours)
  • Betamethasone: Long (36-72 Hours)
Approximate Dexamethasone (Decadron) (IV or PO) Equivalence to MethylPrednisoLONE (Solu-Medrol) (IV or PO)

You are converting to a drug with a longer half-life, consider reducing dosing frequency.

 

Duration of Action:

Dexamethasone: Long (36-72 Hours)
MethylPrednisoLONE: Medium (12-36 Hours)

Approximate Betamethasone (IV) Equivalence to MethylPrednisoLONE (Solu-Medrol) (IV or PO)

You are converting to a drug with a longer half-life, consider reducing dosing frequency.

 

Duration of Action:

  • Betamethasone: Long (36-72 Hours)
  • MethylPrednisoLONE: Medium (12-36 Hours)
Approximate MethylPrednisoLONE (Solu-Medrol) (IV or PO) Equivalence to PrednisoLONE (PO)
Approximate Cortisone (PO) Equivalence to Triamcinolone (IV)

You are converting to a drug with a shorter half-life, consider increasing dosing frequency.

 

Duration of Action:

  • Cortisone: Short (8-12 Hours)
  • Triamcinolone: Medium (12-36 Hours)
N/A

You have chosen the same drugs. Please try again.

Approximate PredniSONE (PO) Equivalence to Dexamethasone (Decadron) (IV or PO)

You are converting to a drug with a shorter half-life, consider increasing dosing frequency.

 

Duration of Action:

  • Prednisone: Medium (12-36 Hours)
  • Dexamethasone: Long (36-72 Hours)
Approximate Hydrocortisone (IV or PO) Equivalence to Betamethasone (IV)

You are converting to a drug with a shorter half-life, consider increasing dosing frequency.

 

Duration of Action:

  • Hydrocortisone: Short (8-12 Hours)
  • Betamethasone: Long (36-72 Hours)
Approximate Dexamethasone (Decadron) (IV or PO) Equivalence to Cortisone (PO)

You are converting to a drug with a longer half-life, consider reducing dosing frequency.

 

Duration of Action:

  • Dexamethasone: Long (36-72 Hours)
  • Cortisone: Short (8-12 Hours)
Approximate PrednisoLONE (IV or PO) Equivalence to PredniSONE (PO)
Approximate Hydrocortisone (IV or PO) Equivalence to MethylPrednisoLONE (Solu-Medrol) (IV or PO)

You are converting to a drug with a shorter half-life, consider increasing dosing frequency.

 

Duration of Action:

  • Hydrocortisone: Short (8-12 Hours)
  • MethylPrednisoLONE: Medium (12-36 Hours)
Approximate Betamethasone (IV) Equivalence to PredniSONE (PO)

You are converting to a drug with a longer half-life, consider reducing dosing frequency.

 

Duration of Action:

Betamethasone: Long (36-72 Hours)
PredniSONE: Medium (12-36 Hours)

Approximate Hydrocortisone (IV or PO) Equivalence to PrednisoLONE (PO)

You are converting to a drug with a shorter half-life, consider increasing dosing frequency.

 

Duration of Action:

  • Hydrocortisone: Short (8-12 Hours)
  • MethylPrednisoLONE: Medium (12-36 Hours)
Approximate PrednisoLONE (PO) Equivalence to Betamethasone (IV)

You are converting to a drug with a shorter half-life, consider increasing dosing frequency.

 

Duration of Action:

  • PrednisoLONE: Medium (12-36 Hours)
  • Betamethasone: Long (36-72 Hours)

引用

Bornstein SR, Allolio B, Arlt W, Barthel A, Don-Wauchope A, Hammer GD, Husebye ES, Merke DP, Murad MH, Stratakis CA, Torpy DJ. Diagnosis and Treatment of Primary Adrenal Insufficiency: An Endocrine Society Clinical Practice Guideline. J Clin Endocrinol Metab. 2016 Feb;101(2):364-89. doi: 10.1210/jc.2015-1710. Epub 2016 Jan 13. PMID: 26760044; PMCID: PMC4880116.

文献

  • Potency and duration of action of glucocorticoids. Effects of hydrocortisone, prednisone and dexamethasone on human pituitary-adrenal function. Am J Med. 1977 Aug;63(2):200-7.

    Meikle AW, Tyler FH.

    https://pubmed.ncbi.nlm.nih.gov/888843/

  • Pharmacokinetics and pharmacodynamics of systemically administered glucocorticoids. Clin Pharmacokinet. 2005;44(1):61-98.

    Czock D, Keller F, Rasche FM, Häussler U.

    https://pubmed.ncbi.nlm.nih.gov/15634032/

  • Oxford Handbook of Critical Care, 3 edn, Oxford Medical Handbooks (Oxford, 2009; online edn, Oxford Academic, 1 Aug. 2010)

    Singer, Mervyn, and Andrew Webb

    https://academic.oup.com/book/29992

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